This book explains how the immune system functions, namely, how individual cells of the immune system make the decision to respond or not to respond to foreign microbes and molecules, and how the critical molecules function to trigger the cellular reactions in an all or none quantal manner To date, there has not been a complete description of the immune system and its cells and molecules, primarily because most of the information has accumulated only in the last 40 years and our understanding has been expanding rapidly only in the last 20 years It is now clear that the cells have evolved a way to count the number of foreign antigenic molecular hits , and they only react when a critical number of events have accumulated Subsequently, control over the reaction is transferred to a systemic lymphocytotrophic hormone system that determines the tempo, magnitude and duration of the immune reaction This book explains in detail how the immune system, cells and molecules work for the first time With this understanding as a basis, the pathogenesis of autoimmunity can now be understood as a mutational usurpation of the genes encoding molecules that participate in a sensitive feedback regulatory control of the immune reaction By comparison, malignant transformation is understood as a mutational usurpation of the genes encoding the molecules that control the quantal decision to proliferate, so that normal ligand receptor cell growth control is circumvented....
|Title||:||The Quantal Theory of Immunity: The Molecular Basis of Autoimmunity and Leukemia|
|Publisher||:||World Scientific Publishing Company 1 edition August 18, 2010|
|Number of Pages||:||244 pages|
|File Size||:||688 KB|
|Status||:||Available For Download|
|Last checked||:||21 Minutes ago!|